Fig. 6

Construction of 6-gene signature prognosis model. A Forest plot of Univariate COX analysis. B, C Coefficient estimates and cross-validation error of the Lasso regression results. D Risk curve, survival scatter plot analysis and heat maps of expression profiles of 6 metabolic genes of patients with high- and low-risk in the training set of the 6-gene signature prognosis model. E mRNA expression levels of the 6 metabolic genes in 3 subclusters. F Kaplan–Meier curve shows the overall survival of high- and low-risk RCC patients. G Time-dependent receiver operating characteristic (ROC) curve analysis exhibits the prognostic performance of the 6-gene-signature-based prognostic model in predicting 1 ~ 5-year survival times of the training group