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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3

Fig. 6

GSK-650394 inhibits the activation of PMN-MDSCs in CRLM Mice after IR. After intraperitoneal injection of GSK-650394, a mouse CRLM + IR model was established. A Immunofluorescence detection of Ly6G, CD36 expression in mouse liver (n = 4 samples/group). Scale bars, 50 μm. B Quantification of CD36 and Ly6G immunofluorescence, (n = 4 samples/group). C Peripheral blood neutrophils were extracted to detect CD84 expression by flow cytometry (n = 4 samples/group). D Elisa detection of LOX1 levels from serum from patients with CRLM 1 day after surgery. SGK1 expression of livers from patients with CRLM undergoing partial hepatectomy was detected by Quantitative RT-PCR. Correlation of LOX1 with SGK1 (n = 16 samples). E The expression of SGK1 and LOX1 in tumor and adjacent tumor of patients with CRLM was detected by immunofluorescence, and healthy liver tissue was used as control group (n = 4 samples/group). Scale bars, 50 μm. F Quantification of SGK1 and LOX1 immunofluorescence (n = 4 samples/group). All data represent the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001****p < 0.0001

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