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Table 2 The Odds Ratio (OR) estimate of Major osteoporotic fractures (MOF) is derived from two methods in an independent testing dataset (\(n=\mathrm{15,776}\))

From: Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms

 

GPS (LDPred with ρ = 0.03)

GRS (1,103 SNPs from GWAS)

OR (95% CI)

\(p\)-value

OR (95% CI)

\(p\)-value

Top 30% vs. Remaining 70%

1.67 (0.94, 2.82)

0.06

0.72 (0.32, 1.42)

0.38

Top 20% vs. Remaining 80%

2.36 (1.42, 3.80)

0.01

0.82 (0.38, 1.56)

0.57

Top 10% vs. Remaining 90%

2.48 (1.86, 2.76)

 < 0.001

0.97 (0.67, 1.68)

0.11

Top 5% vs. Remaining 95%

3.12 (2.25, 5.42)

 < 0.001

1.25 (0.98, 1.75)

0.13

  1. The odds ratio (OR) was calculated for the top 30%, 20%, 10%, and 5% of the GPS and GRS compared with the remaining individuals. CI confidence interval. The odds ratios were calculated in a multiple logistic regression model adjusted for the clinical risk factors of age, height, weight, parental fracture, previous fracture, smoking, glucocorticoid use, rheumatoid arthritis, hip BMD, and previous osteoporosis. In a separate analysis, we replaced spine BMD with hip BMD. The results were similar, not shown in this table