Table 1 Baseline descriptive statistics of 15,776 women in an independent testing dataset stratified by Major osteoporotic fracture (MOF) status
Variable | Participants without MOF (n = 14,835) | Participants with MOF (n = 941) | P-value* |
|---|---|---|---|
Age (years), mean (SD) | 61.0 (7.07) | 65.5 (7.95) | < 0.001 |
Height (cm), mean (SD) | 162 (5.99) | 161 (6.23) | 0.095 |
Weight (kg), mean (SD) | 82.0 (17.6) | 76.8 (16.4) | < 0.001 |
Hip BMD (g/cm2), mean (SD) | 0.927 (0.150) | 0.840 (0.129) | < 0.001 |
Spine BMD (g/cm2), mean (SD) | 1.03 (0.175) | 0.974 (0.167) | < 0.001 |
GPS**, mean (SD) | 31.8 (132) | 76.0 (147) | < 0.001 |
GRS***, mean (SD) | 31.5 (0.420) | 31.5 (0.366) | 0.009 |
RACE/ethnicity, \(n (\%)\) | |||
American Indian or Alaskan Native | 356 (2.5%) | 46 (4.9%) | < 0.001 |
Asian or Pacific Islander | 4 (< 1%) | 8 (0.9%) | |
Black or African-American | 8742 (58.9%) | 249 (26.5%) | |
Hispanic/Latino | 2761 (18.6%) | 168 (17.9%) | |
Not-Hispanic White | 2957 (19.9%) | 470 (49.8%) | |
Smoking, \(n (\%)\) | |||
Never Smoked | 8672 (58.5%) | 472 (50.2%) | < 0.001 |
Past Smoker | 4833 (32.5%) | 419 (44.5%) | |
Current Smoker | 1183 (8.0%) | 50 (5.3%) | |
Rheumatoid Arthritis, \(n (\%)\) | 1260 (8.5%) | 150 (15.9%) | < 0.001 |
Previous fragility fracture, \(n (\%)\) | 426 (2.9%) | 7 (0.7%) | < 0.001 |
Previous osteoporosis, \(n (\%)\) | 838 (5.6%) | 118 (12.5%) | < 0.001 |
Glucocorticoid use, \(n (\%)\) | 30 (0.2%) | 2 (0.2%) | 1 |
Parental fracture history, \(n (\%)\) | 1142 (7.7%) | 142 (15.1%) | < 0.001 |