Spermatogenesis associated serine rich 2 like plays a prognostic factor and therapeutic target in acute myeloid leukemia by regulating the JAK2/STAT3/STAT5 axis

Table 2 Multivariate analysis of the prognostic significance of SPATS2L on AML from our cohort

Clinical endpoint	Risk factor*	P value	HR(95%CI)
Overall survival(OS)	WBC	0.000	1.007 (1.004,1.010)
	HB	0.039	.0990 (0.981,0.999)
	Blast	0.053	1.011 (1.000,1.022)
	CEBPa	0.006	0.571 (0.381,0.851)
	Age	0.001	1.022 (1.008,1.036)
	SPATS2L	0.025	1.631 (1.064,2.500)
Event free survival(EFS)	WBC	0.000	1.007 (1.005,1.010)
	HB	0.041	0.991 (0.983,1.000)
	CEBPa	0.001	0.592 (0.432,0.812)
	DNMT3A	0.053	1.644 (0.994,2.721)
	Sex	0.031	1.513 (1.039,2.202)
	SPATS2L	0.001	1.894 (1.288,2.786)
Relapse free survival(RFS)	WBC	0.001	1.007 (1.003,1.011)
	CEBPa	0.105	0.720 (0.485,1.071)
	Flt3-ITD	0.064	1.928 (0.963,3.861)
	IDH2	0.020	0.085 (0.011,0.676)
	Age	0.067	1.011 (0.999,1.034)
	SPATS2L	0.000	3.345 (1.883.5.943)

Multivariate analysis were performed by Cox proportional hazards models with the backward likehood stepwise procedures, risk factors that are not in the cox regression analysis equation are not shown in the Table2
HR hazard ratio, CI confidence interval
^*: As for multivariate analysis, the risk factor included age,sex,WBC,HB,PLT,BM blast,FAB type, Karyotype Risk, gene mutations (FLT3-ITD,NPM1,CEBPA,IDH1,IDH2,DNMT3A), treatment protocols

ISSN: 1479-5876