Fig. 5

The regulating mechanism of SPATS2L in AML. A Integrative analysis of our SPTS2L KD RNA-seq data and TCGA AML RNA-seq data was performed to identify pathways or gene sets commonly enriched by GSEA. Nine gene sets were identified to be affected by both our and TCGA data. B Normalized enrichment scores (NES) of the six gene sets. C Among the nine signaling pathways, IL6-JAK-STAT3-SIGNALING and IL2-STAT5-SIGNALING were significantly suppressed, and the two pathways were most correlated with AML. D The changes of proteins JAK2/STAT3/STAT5 were measured by western-blot