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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Spermatogenesis associated serine rich 2 like plays a prognostic factor and therapeutic target in acute myeloid leukemia by regulating the JAK2/STAT3/STAT5 axis

Fig. 4

The inhibition of SPATS2L in AML can prolong the survival of AML mice. A Schematic illustration of the THP-1 AML xenograft NCG model coupled with control and shRNA targeting SPATS2L KD. B The human CD45 expression of PB and BM cells for the last time in mice was measured by flow cytometry. C The survival curves of the three groups. D Schematic illustration of the THP-1luc AML xenograft NCG model coupled with a control or shRNA targeting SPATS2L KD. E In vivo imaging results of the abdomen of mice on the 7th, 14th, and 21st day after cell injection. E Quantitative analysis results of in vivo imaging results of the abdomen of mice. F Kaplan–Meier curves of the three groups xenotransplanted with human THP-1 luc AML cells. NS not significance, P < 0.05 *, P < 0.01 **, P < 0.001 ***

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