Fig. 7
Source data are available in Additional file 1: Table S5. b Kaplan–Meier analyses of the correlation between VBP1 and RAN levels and the disease-free survival and overall survival in 716 patients with breast cancer from TCGA database. c Constructed LacRNA and LacRNA-mediated c-Myc signaling downregulation nomogram to predict 3-year, 5-year overall survival for patients, with LacRNA, VBP1, RAN, T stage, N stage, ER status and PR status. d Comparisons of the prognostic accuracy by the nomogram, LacRNA and clinicopathological factors. e Scatter plots comparing LacRNA expression in paired adjacent normal breast tissues, breast cancer tissues and positive lymph node tissues (n = 30) by RT-qPCR. Statistical significance was determined by Kruskal–Wallis test., ***P < 0.001, ****P < 0.0001 f Kaplan–Meier analyses of the correlation between LacRNA levels and the disease-free survival and overall survival in 530 patients with breast cancer from FUSCC
LacRNA-dependent c-Myc signaling downregulation correlates with improved survival in breast cancer. a Gene expression correlation analysis of c-Myc downstream pathways using through RNA-seq data of 1,094 breast cancer samples from the TCGA database. The correlations between LacRNA and Myc target expression levels were evaluated using the Pearson correlation coefficient test.