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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Automating iPSC generation to enable autologous photoreceptor cell replacement therapy

Fig. 5

Gene expression in single cells from retinal organoids. A Two-dimensional (uniform manifold approximation and projection) UMAP embedding of organoid-derived cells shows presence of distinct neural retina cell types at day 120 of differentiation. B Expression of cell type-specific marker genes is shown based on shading of individual cells. Rod photoreceptors express NRL, cone photoreceptors express PDE6H, all photoreceptors express RCVRN, and progenitor and inner retinal populations express PAX6. C Two-dimensional PHATE embedding of cells in the rod lineage demonstrates organoid-derived cells across different stages of differentiation. D Two-dimensional UMAP embedding of organoid-derived cells from this study integrated with those from a previous study [52]. E Cells in D colored by study of origin. UI = cells from the current study (generated at University of Iowa), UW = cells from a previous study ( [52] generated at University of Washington). The cells generated via the method described in the current study integrate efficiently with those described previously

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