Table 2 Linear peptides of SARS-CoV-2 proteome differentially recognized by IgG of adults and children
From: Immune profiling of SARS-CoV-2 epitopes in asymptomatic and symptomatic pediatric and adult patients
Peptide | Organism | Protein | Sequence* | p-value | Comparison groups | AUC |
|---|---|---|---|---|---|---|
Adults | ||||||
NCAP_SARS2_0157-0171 | SARS-CoV-2 | N | IVLQLPQGTTLPKGF | 9.9X10−3 | Mild/Sev | 0.773 |
NCAP_SARS2_0161-0175 | SARS-CoV-2 | N | LPQGTTLPKGFYAEG | 4.9X10−3 | Mild/Sev | 0.796 |
NCAP_SARS2_0221-0235 | SARS-CoV-2 | N | LLLLDRLNQLESKMS | 1.6X10−5 | Mild/Sev | 0.924 |
NCAP_SARS2_0393-0407 | SARS-CoV-2 | N | TLLPAADLDDFSKQL | 1X10−3 | Mild/Sev | 0.84 |
SPIKE_SARS2_0557-0571 | SARS-CoV-2 | S | KKFLPFQQFGRDIAD | 8.6X10−3 | Mild/Sev | 0.778 |
SPIKE_SARS2_0785-0799 | SARS-CoV-2 | S | VKQIYKTPPIKDFGG | 1X10−4 | Mild/Sev | 0.889 |
SPIKE_SARS2_0789-0803 | SARS-CoV-2 | S | YKTPPIKDFGGFNFS | 2X10−3 | Mild/Sev | 0.822 |
SPIKE_SARS2_1145-1159 | SARS-CoV-2 | S | LDSFKEELDKYFKNH | 1.2X10−3 | Mild/Sev | 0.836 |
R1A_R1AB_SARS2_0249-0263 | SARS-CoV-2 | 1A-1AB | YELQTPFEIKLAKKF | 4.8X10−3 | Asym/mild | 0.926 |
R1AB_SARS2_6073-6087 | SARS-CoV-2 | 1AB | HLIPLMYKGLPWNVV | 5.7X10−3 | Mild/Sev | 0.791 |
Children | ||||||
NCAP_SARS2_0109-0123 | SARS-CoV-2 | N | YFYYLGTGPEAGLPY | 9.1X10−3 | Ped/Mild | 0.2 |
NS7A_SARS2_0009-0023 | SARS-CoV-2 | NS7A | LITLATCELYHYQEC | 3.2X10−3 | Ped/Mild | 0.18 |
NS8_SARS2_0033-0047 | SARS-CoV-2 | NS8 | VDDPCPIHFYSKWYI | 5.9X10−3 | Ped/Mild | 0.2 |
R1A_R1AB_SARS2_2001-2015 | SARS-CoV-2 | 1A-1B | ATYKPNTWCIRCLWS | 3X10−4 | Ped/Mild | 0.12 |
R1A_R1AB_SARS2_2157-2171 | SARS-CoV-2 | 1A-1B | VTRCLNRVCTNYMPY | 1.3X10−5 4.3X10−3 | Ped/Mild Ped/Sev | 0.07 0.2 |
R1A_R1AB_SARS2_3005-3019 | SARS-CoV-2 | 1A-1B | VLNNDYYRSLPGVFC | 5X10−4 | Ped/Mild | 0.13 |
R1A_R1AB_SARS2_3469-3483 | SARS-CoV-2 | 1A-1B | AWLYAAVINGDRWFL | 5.1X10−3 | Ped/Mild | 0.2 |
R1A_R1AB_SARS2_4269-4283 | SARS-CoV-2 | 1A-1B | FCAFAVDAAKAYKDY | 3.7X10−3 | Ped/Mild | 0.19 |
R1AB_SARS2_4541-4555 | SARS-CoV-2 | 1A-1B | YNCCDDDYFNKKDWY | 9.1X10−3 | Ped/Mild | 0.2 |
R1AB_SARS2_4653-4667 | SARS-CoV-2 | 1A-1B | LTKPYIKWDLLKYDF | 1X10−4 | Ped/Mild | 0.1 |
R1AB_SARS2_4673-4687 | SARS-CoV-2 | 1A-1B | KLFDRYFKYWDQTYH | 1.6X10−3 | Ped/Mild | 0.16 |
R1AB_SARS2_4725-4739 | SARS-CoV-2 | 1A-1B | IFVDGVPFVVSTGYH | 6.8X10−3 | Ped/Mild | 0.2 |
R1AB_SARS2_4729-4743 | SARS-CoV-2 | 1A-1B | GVPFVVSTGYHFREL | 7.9X10−3 | Ped/Mild Ped/Sev | 0.2 0.16 |
R1AB_SARS2_4809-4823 | SARS-CoV-2 | 1A-1B | KDFYDFAVSKGFFKE | 5.9X10−3 | Ped/Mild | 0.2 |
R1AB_SARS2_4845-4859 | SARS-CoV-2 | 1A-1B | YDYYRYNLPTMCDIR | 6X10−4 | Ped/Mild | 0.14 |
R1AB_SARS2_5273-5287 | SARS-CoV-2 | 1A-1B | FHLYLQYIRKLHDEL | 5X10−4 | Ped/Mild | 0.13 |
R1AB_SARS2_5829-5843 | SARS-CoV-2 | 1A-1B | AWRKAVFISPYNSQN | 6.8X10−3 | Ped/Sev | 0.27 |
R1AB_SARS2_6073-6087 | SARS-CoV-2 | 1A-1B | HLIPLMYKGLPWNVV | 4X10−4 | Ped/Mild | 0.133 |
R1AB_SARS2_6153-6167 | SARS-CoV-2 | 1A-1B | HHSIGFDYVYNPFMI | 2.7X10−3 | Ped/Mild | 0.18 |
R1AB_SARS2_6681-6695 | SARS-CoV-2 | 1A-1B | GYAFEHIVYGDFSHS | 7.9X10−3 | Ped/Mild | 0.2 |
R1AB_SARS2_6973-6987 | SARS-CoV-2 | 1A-1B | SWNADLYKLMGHFAW | 1.3X10−3 | Ped/Mild | 0.16 |
SPIKE_SARS2_0133-0147 | SARS-CoV-2 | S | FQFCNDPFLGVYYHK | 8X10−4 | Ped/Mild | 0.148 |
SPIKE_SARS2_0265-0279 | SARS-CoV-2 | S | YYVGYLQPRTFLLKY | 7.9X10−3 | Ped/Sev | 0.214 |
SPIKE_SARS2_0325-0339 | SARS-CoV-2 | S | SIVRFPNITNLCPFG | 1.6X10−3 2.7X10−3 | Ped/Mild Ped/Sev | 0.167 0.181 |
SPIKE_SARS2_0553-0567 | SARS-CoV-2 | S | TESNKKFLPFQQFGR | 3.7X10−3 | Ped/Mild | 0.19 |
SPIKE_SARS2_0557-0571 | SARS-CoV-2 | S | KKFLPFQQFGRDIAD | 3.2X10−3 | Ped/Mild | 0.186 |
SPIKE_SARS2_0785-0799 | SARS-CoV-2 | S | VKQIYKTPPIKDFGG | 2.7X10−3 | Ped/Mild | 0.181 |
SPIKE_SARS2_1201-1215 | SARS-CoV-2 | S | QELGKYEQYIKWPWY | 9X10−4 | Ped/Mild | 0.15 |
SPIKE_SARS2_1205-1219 | SARS-CoV-2 | S | KYEQYIKWPWYIWLG | 3.7X10−3 | Ped/Mild | 0.19 |
VME1_SARS2_0005-0019 | SARS-CoV-2 | M | NGTITVEELKKLLEQ | 7.9X10−3 | Ped/Mild | 0.2 |