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Table 4 AI662270 promotes cardiac function decline in ApoE−/− mice with high fat diet (HFD)

From: Genetic dissection of the impact of lncRNA AI662270 during the development of atherosclerosis

 

CD

HFD

Lv-null + HFD

Lv-AI662270 + HFD

EF (%)

69.62 ± 4.32

48.72 ± 7.08***

52.89 ± 6.57

34.97 ± 3.17##

FS (%)

38.14 ± 3.25

23.63 ± 5.08***

23.93 ± 3.66

16.58 ± 1.50#

LVPW, d (mm)

0.83 ± 0.29

0.93 ± 0.28

0.93 ± 0.28

0.66 ± 0.17

LVPW, s (mm)

1.18 ± 0.32

1.28 ± 0.46

1.30 ± 0.27

0.82 ± 0.22

LVID, d (mm)

3.17 ± 0.37

3.74 ± 0.73

3.73 ± 0.70

4.47 ± 0.75

LVID, s (mm)

1.97 ± 0.31

3.05 ± 0.52**

2.84 ± 0.56

3.90 ± 0.45#

HR, (bmp)

507.83 ± 8.43

564.17 ± 3.75**

573.5 ± 11.2

606.17 ± 6.04##

  1. n = 6. **p < 0.01 or ***p < 0.001 vs. mice in chow diet (CD); #p < 0.05 or ##p < 0.01 vs. Lv-null treated mice in high fat diet (HFD). Data are expressed as mean ± SEM
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