Fig. 6
From: Abnormal signal pathways and tumor heterogeneity in osteosarcoma
Etoposide exerts effective palliation by affecting the subtype of OS and correcting abnormal pathways. A Box plot and corresponding stacked histogram show immunogenic subtype score in metastasis and no metastasis OS samples. B Immunogenic subtype score in OS samples across various Huvos grades. C Enrichment of immunogenic subtype gene signature in DrugMatrix dataset. D, E The GSEA enrichment plot and dose-dependent heatmap showed the effect of etoposide on immunogenic and adipocyte-like subtypes. F GSVA analysis was used to determine the different tendencies between immunogenic and adipocyte-like subtypes with different concentrations of etoposide. G Osteosarcoma associated mutant genes in Simple ClinVar datasets. H, I The GSEA enrichment plot and dose-dependent heatmap revealed the effect of etoposide on the cell cycle and p53 signaling pathway. J The correlation analysis between immunogenic subtype and Antigen processing and presentation pathway. K Overview of the abnormal signal pathways and tumor heterogeneity in osteosarcoma