Fig. 5From: Abnormal signal pathways and tumor heterogeneity in osteosarcomaDeficient TGFβ signaling leads to adipocyte-like subtype of OS during development. A Principal component analysis (PCA) biplot of transcriptional profiles with 95% confidence ellipsoids in the panels of hMSC, hMSC_BMP2+IBMX and hMSC_BMP2+IBMX+TGFβ (GSE84500). B Heat map shows the significantly different genes in these three groups (log2FC > 1; P < 0.01), and enrichment of cell types in PanglaoDB Augmented Datasets. C Enrichment of BioPlanet signal pathway in hMSC_BMP2+IBMX+TGFβ group. D Sketch map of TGFβ signaling in OS development. E Box plot and corresponding stacked histogram demonstrate the correlation between metastasis and adipocyte-like subtype score. F Huvos grading system was used to judge the effectiveness of neoadjuvant chemotherapy on OSBack to article page