Alternation of the gut microbiota in irritable bowel syndrome: an integrated analysis based on multicenter amplicon sequencing data

Table 2 Representative microbes that might involve in IBS pathogenesis

NCBI_taxa_ID	Rank	Taxon_name	Phylum	Significantly changed*	Trend in IBS	Top 20 in RF	Hub taxon
Taxon543	Family	Enterobacteriaceae	Proteobacteria	√	Enriched	–	–
Taxon1301	genus	Streptococcus	Firmicutes	√	Enriched	√	×
Taxon216851	genus	Faecalibacterium	Firmicutes	√	Depleted	√	×
Taxon1678	genus	Bifidobacterium	Actinobacteria	√	Depleted	√	×
Taxon2719313	genus	Enterocloster	Firmicutes	√	Enriched	√	×
Taxon35832	genus	Bilophila	Proteobacteria	√	Depleted	√	×
Taxon216816	Species	Bifidobacterium_longum	Actinobacteria	√	Depleted	√	×
Taxon1685	Species	Bifidobacterium_breve	Actinobacteria	√	Depleted	√	×
Taxon1680	Species	Bifidobacterium_adolescentis	Actinobacteria	√	Depleted	√	×
Taxon78342	Species	Bifidobacterium_gallicum	Actinobacteria	√	Depleted	√	×
Taxon1755626	Species	Faecalibacterium_sp._MC_41	Firmicutes	√	Depleted	×	√
Taxon853	Species	Faecalibacterium_prausnitzii	Firmicutes	√	Depleted	×	√
Taxon61171	Species	Holdemania_filiformis	Firmicutes	√	Enriched	√	×
Taxon89014	Species	Blautia_luti	Firmicutes	√	Depleted	×	√
Taxon360807	Species	Roseburia_inulinivorans	Firmicutes	√	Depleted	×	√

IBS irritable bowel syndrome, NCBI National Center for Biotechnology Information, RF random forest
^*The relative abundance of IBS patients was compared with healthy controls, using the Mann–Whitney test. Significantly changed taxon was considered with a p-value < 0.05

ISSN: 1479-5876