Fig. 2

The differential analysis of microbiota compositions between IBS and healthy controls at the phylum, family and genus levels. A: The vertical bar chart presenting the microbiota compositions between IBS and healthy controls at the phylum level. The x-axis represents each sample and its group. The y-axis represents the relative abundance. B: Boxplots showing the relative abundance of eight phyla, Firmicutes/Bacteroidetes (F/B) ratio and Firmicutes/Proteobacteria (F/P) ratio between the IBS and healthy controls. C: Horizontal Lollipop plots representing the median relative abundance of significantly enriched or depleted families between the IBS and healthy controls. D: Manhattan plots showing the distributions of each genus identified in IBS and healthy individuals. Significantly-enriched genera are depicted as transparent triangles, significantly-depleted genera are presented as inverted solid triangles, and genera with no statistical significance are depicted as full circles. The dashed line corresponds to the p-value threshold of significance (p = 0.05). The color of each dot represents the different phylum affiliations. The size stands for their relative abundance. The green boxes are used to denote different phylum groups.The Wilcoxon Rank Sum Test was performed and *, **, *** stands for p-value < 0.01, 0.005 and 0.001, respectively)