Table 3 Effects and mechanisms of lncRNAs in periodontium remodeling during OTM.
From: Role of noncoding RNAs in orthodontic tooth movement: new insights into periodontium remodeling
lncRNA | Model | Level | Target | Effect | Mechanism | Study | |
|---|---|---|---|---|---|---|---|
DANCR | MC3T3-E1 cells (compressive force) | ↓ | – | Reduced DANCR inhibited osteoblast differentiation | NF-κB pathway | [153] | |
|  | PDLCs (compressive force), OCPs | ↑ | Jagged1 | Reduced DANCR inhibited osteoclast formation | miR-34a-5p/DANCR-Jagged1 | [91] | |
FER1L4 | PDLSCs (compressive force), BALB/c mice (OTM) | ↑ | – | Promoted autophagy | AKT/FOXO3 pathway | [131] | |
H19 | BMMSCs (stretch force) | ↑ | miR-138 | Promoted osteoblast differentiation | miR-138/PTK2 axis | [42] | |
MIR31HG | PDLSCs (compressive force) | ↓ | Prompter targeted by DNMT1 and DNMT3B | Inhibited proliferation | DNMT-mediated DNA methylation | [108] | |
Nron | Nron transgenic C57BL/6J mice (OTM) | ↓ | – | Inhibited osteoclast differentiation | Reduced NFATc1 nuclear import | [113] | |
p21 | IMCC (compressive force), C57BL/6 mice (OTM) | ↑ | FOXO3 | Inhibited autophagy and osteoblast function | p21/FOXO3 axis | [130] | |
SNHG8 | PDLSCs (stretch force), Wistar rats (OTM) | ↓ | Promoter targeted by EZH2 | Reduced SNHG8 promoted osteogenic differentiation and bone formation | Erichment of H3K4me3 in the SNHG8 promoter | [123] | |
|  | PDLCs (compressive force), SD rats (OTM) | ↓ | HIF-1α | Reduced SNHG8 promoted hypoxia and inflammation | NF-κB pathway by releasing functional HIF-1α | [50] | |
TUG1 | MC3T3-E1 cells (fluid shear stress) | ↑ | miR-34a | Promoted proliferation and inhibited apoptosis | TUG1/miR- 34a/FGFR1 axis | [107] | |
|  | PBMCs, SD rats (OTM) | ↑ | MafB | Promoted osteoclast differentiation | – | [114] | |
circ_0008542 | MC3T3-E1 cells (stretch force) | ↑ | miR-185-5p | Promoted osteoclast differentiation | circ_0008542/miR-185-5p/RANK axis | [111] | |