From: Role of noncoding RNAs in orthodontic tooth movement: new insights into periodontium remodeling
miRNA | Model | Level | Target | Effect | Mechanism | Study | |
---|---|---|---|---|---|---|---|
miR-20a | MC3T3-E1 cells (fluid shear stress) | ↑ | BAMBI, SMAD | Promoted osteoblast differentiation | BMP2 pathway | [78] | |
miR-21 | miR-21−/− mice (OTM) | – | PDCD4, RANKL | Promoted osteoclast differentiation | c-Fos/miR-21/PDCD4 positive feedback loop, RANKL/OPG | [110] [63] | |
 | PDLSCs (stretch force), PDLCs, SD rats (OTM) | ↑ | ACVR2B, PLAP-1, HIF-1α | Promoted osteoblast differentiation | TGF-β pathway | [118] | |
miR-26a | PDLCs (compressive force), SD rats (OTM) | ↓ | Promoter targeted by Runx1 | Inhibited osteoclast differentiation | Runx1/miR-26a/Jagged1 signaling axis | [115] | |
miR-34a | rBMSCs (stretch force), Wistar rats (OTM) | ↑ | GSK-3β | Promoted osteoblast differentiation | Wnt/β-catenin pathway | [124] | |
 | PDLSCs (stretch force) | ↓ | CELF3 | Inhibited osteoblast differentiation | miR-34a/miR146a-CELF3 | [120] | |
miR-34c-5p | PDLFs (aseptic inflammation) | ↑ | SATB2 | Inhibited PDLSC osteogenic differentiation and bone formation | miR-34c-5p/SATB2/ERK | [121] | |
miR-125a-5p | PDLCs from orthodontic patients | ↑ | ETV6 | Promoted macrophage M2 polarization and osteogenesis | – | [134] | |
miR-132 | PDLCs (fluid shear stress) | ↑ | – | Promoted proliferation and osteogenic differentiation | PI3K/AKT/mTOR pathway | [102] | |
miR-132-3p | MC3T3-E1 cells (stretch force) | ↑ | SMAD5 | Inhibited osteoblast differentiation | – | [125] | |
miR-140 | PDLFs from orthodontic patients | – | RhoA | Inhibited osteoblast differentiation | RhoA-TAZ axis | [48] | |
miR-146a-5p | Osteoclasts (compressive force), SD rats (OTM) | ↓ | ADP | Promoted osteoclastogenesis and angiogenesis | miR-146a-ADP feedback loop | [135] | |
miR-155-5p | Patients with OIIRR | ↓ | CXCR2 | Inhibited osteoclast differentiation | IL-8/CXCR2 axis | [133] | |
miR-181b-5p | Osteocyte-like MLO-Y4 cells (stretch force) | ↑ | PTEN | Promoted PDLSC proliferation and osteogenic differentiation | miR-181b-5p/PTEN/AKT signaling | [104] | |
miR-195-5p | PDLCs (stretch force), C57BL/6 mice (OTM) | ↓ | WNT3A, FGF2, BMPR1A | Inhibited osteoblast differentiation | WNT and BMP signaling | [28] | |
miR-494-3p | MC3T3-E1 cells (compressive force) | ↑ | FGFR2, ROCK1 | Inhibited proliferation | – | [47] | |
miR-3198 | PDLCs (stretch force), (compressive force) | ↓ ↑ | OPG | Regulated osteoclast differentiation | RANKL/OPG | [23] |