Fig. 9

The underlying biological function characteristics of different m6A modification subtypes. A The differentially expressed genes between two subtypes. B The top 10 of GO-BP enrichment analysis of the above differentially expressed genes. C The sample clustering was performed according to the expression data of all samples. D Analysis of the scale free ft index and analysis of the mean connectivity for various soft-thresholding powers. E Gene dendrogram obtained by average linkage hierarchical clustering. The color row underneath the dendrogram shows the module assignment determined by the Dynamic Tree Cut, in which 12 modules were identified. F The heatmap showed the correlation between module eigengenes and the two modification patterns. G A scatterplot of gene significance (GS) for subtype-2 versus module membership (MM) in the yellow module. GS and MM exhibit a very significant correlation, implying that hub genes of the yellow module also tend to be highly correlated with subtype-2