Fig. 4
From: ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway
Molecular docking and simulation analyses of the interaction between ApoE and ACE2. A-C Predicted binding mode of ACE2 with ApoE2, ApoE3 or ApoE4 (the orange region of the ACE2 protein represents the region that binds to the S1 unit of the spike protein, and amino acids 112 and 158 of the ApoE protein are represented by spheres). D-F The three-dimensional mode and structural representation of the interface residues of the ApoE and ACE2 complexes (dotted green lines indicate hydrogen bonds, and blue and purple lines represent amino acid residues in ACE2 and ApoE proteins, respectively)