Fig. 5

Metabolic signature upon starvation with doxorubicin and correlation with clinical outcome. a Kaplan–Meier survival curves depicting that elevated levels of FOXO1 and PPARGC1B are associated with prolonged relapse-free survival in all breast cancer breast subtypes (All) including TNBC. b ROC curve analysis depicting that elevated levels of FOXO1 and PPARGC1B are associated with improved response to anthracycline treatment in TNBC. c Kaplan–Meier survival plots depicting the correlation between intracellular concentrations of the selected metabolites with patient’s prognosis in a TNBC cohort. Decreased levels of stearoylcarnitine, butyrylcarnitine and glycerophosphorylcholine being observed upon STS + DXR in MDA-MB-231 cells, are all associated with favorable clinical outcome