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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming

Fig. 2

Differential metabolic responses to starvation and chemotherapy in malignant and near normal breast cell lines. a Oxygen consumption rate (OCR) measurements in MCF-10A and MDA-MB-231 cells treated with DXR or combined treatment (STS + DXR), using the Seahorse Analyzer. Combination treatment selectively decreases mitochondrial oxidative phosphorylation in breast cancer cells. Data are presented as mean of OCR ± SD. b Extracellular Acidification Rate (ECAR) measurements in MCF-10A and MDA-MB-231 cells treated with DXR or STS + DXR, using Seahorse Analyzer. Glycolytic function is preserved in DXR and is reduced in MCF-10A with STS + DXR, but not in MDA-MB-231. Data are presented as mean ECAR ± SD

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