Fig. 4
From: Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma
PFK15 inhibits HemEC migration and induces apoptosis. A, Effects of PFK15 on HemEC migration. *, P < 0.05; **, P < 0.01; ***, P < 0.001. B, Effects of PFK15 on HemEC apoptosis. *, P < 0.05; **, P < 0.01; ***, P < 0.001. C, Apoptosis pathway-related protein expression after PFK15 treatment. D, Effects of PFK15 on ultrastructural changes in HemEC mitochondria. E, Effects of PFK15 on reactive oxygen species (ROS) production, as evaluated by fluorescence microscopy. ***, P < 0.001; ns, no significance. F, Effects of PFK15 on ROS production, as evaluated by flow cytometry. ****, P < 0.0001; ns, no significance