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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin

Fig. 2

BV stimulates CRC angiogenesis by secreting VEGFA. A, B The expression of VEGFA was detected by RT-qPCR and ELISA in HCT116, SW480 and SW620 cells cultured with BV. C Cell migration in HUVECs were examined by transwell assays after HUVECs were plated and cocultured with the CM from HCT116 and SW480 treated with BV. One representative image from three reproducible experiments is shown. Scale bar, 50 μm. Migrated HUVEC numbers are shown in the bar graph. D Tubule formation of HUVECs was shown in representative images after co-incubating with the CM from BV treated HCT116 and SW480. Scale bar, 100 μm. The increasing folds of tube formation is shown in the bar graph. **P < 0.01, ***P < 0.001, ****, P < 0.0001

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