Table 1 The details of hub genes
From: Identification of novel immune subtypes and potential hub genes of patients with psoriasis
No. | Gene | Full name | Function |
|---|---|---|---|
1 | PPIF | Peptidylprolyl isomerase F | A member of the peptidyl-prolyl cis–trans isomerase family, which is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death |
2 | SOD2 | Superoxide dismutase 2 | A member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein, which binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen |
3 | GYS1 | Glycogen synthase 1 | Catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of α-1,4-glycoside linkages |
4 | AHCY | Adenosylhomocysteinase | Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine |
5 | PGD | Phosphogluconate dehydrogenase | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH |