Fig. 3

Correlation and difference analysis of IMs expression between PBLs and TILs. A The difference and correlation analysis of PD-1, TIM-3 and PD-L1 expression between CD8⁺PBLs and CD8⁺TILs. The expression of PD-1, TIM-3 and PD-L1 on CD8⁺T cells in TILs and corresponding PBLs (n = 47). The dots of the same shape and color denote the same patients. B Correlation analysis between IMs⁺CD8⁺TILs, and AMs⁺CD8⁺PBLs and IMs⁺CD8⁺PBLs in 47 patients. The analysis was performed using samples from the same patients. C The consistency analysis between two clusters of TIME and the grouping results of single/pairwise/simultaneous combination of three parameters, including the percentage of PD-L1⁺CD8⁺PBLs, TIM-3⁺CD8⁺PBLs and LAG-3⁺CD8⁺PBLs. *P < 0.05, **P < 0.01