Fig. 6

Comparison of T cells and immunotherapy response between three gastric cancer subtypes in GSE183904. A The tSNE plot of T cells profiled colored by 5 T cell types. B Comparison of 5 T cells of three subtypes. Comparison of IFN-γ signaling pathway, IFNG gene, and cytotoxicity score between three subtypes in CD8 + T cell (C) and NK T cell (D). E Comparison of exhaustion score and PDCD1, and LAG3 in NK T cell between three subtypes. F Heatmap displays of 14 cancer functional states for three subtypes in the IMvigor210 cohort. G Comparison of TIDE score, dysfunction score and exclusion score between three subtypes in TCGA-STAD. H Kaplan–Meier curves of OS in the IMvigor210 cohort between three subtypes. I, J Proportion of patients with response to ICI immunotherapy in three subtypes in the IMvigor210 cohort. CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease. CR/PR was identified as responder, and SD/PD was identified as non-responder