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Table 2 Associations between genetic risk score quartiles of sleep duration and metabolic outcomes in the UK Biobank (n = 335,727)

From: Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses

 

GRS

Lowest GRS

Intermediate GRS

Highest GRS

P for trend

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

MetS

Ref

0.98 (0.97, 1.00)

0.118

0.97 (0.95, 0.99)

0.002

0.98 (0.97, 0.99)

0.002

MetS components

       

 Central obesity

Ref

0.96 (0.95, 0.98)

< 0.0001

0.92 (0.90, 0.94)

< 0.0001

0.96 (0.95, 0.97)

< 0.0001

 High blood pressure

Ref

1.00 (0.98, 1.02)

0.937

1.01 (0.99, 1.03)

0.395

1.00 (0.99, 1.01)

0.404

 Dyslipidemia

Ref

1.00 (0.98, 1.02)

0.985

0.99 (0.97, 1.01)

0.401

0.99 (0.98, 1.00)

0.412

 Hypertriglyceridemia

Ref

0.98 (0.97, 1.00)

0.085

0.98 (0.96, 1.00)

0.078

0.99 (0.98, 1.00)

0.074

 Hyperglycemia

Ref

0.98 (0.95, 1.01)

0.118

0.94 (0.90, 0.97)

0.0005

0.97 (0.95, 0.99)

0.0005

  1. GRS: Genetic risk score; MetS: Metabolic syndrome
  2. Each model was adjusted for age, sex, assessment centers, top 10 genetic PCs, genotyping array. Statistical significance was defined as Bonferroni-corrected threshold of P < 0.008 (0.05/6)
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Journal of Translational Medicine

ISSN: 1479-5876

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