Fig. 2
sEH levels in selected tissues from sham, anhedonia-susceptible, and anhedonia-resilient mice. A Levels of the sEH protein in selected tissues. ACC [H2 = 1.865, P = 0.394]; mPFC [F (2, 21) = 8.615, P < 0.01]; NAc [H2 = 0.620, P = 0.733]; Striatum [H2 = 0.695, P = 0.706]; Hippo [F (2, 21) = 6.145, P < 0.01]; Cerebellum [F (2, 21) = 2.75, P = 0.087]; Spinal cord [F (2, 21) = 3.457, P = 0.05]; Heart [H2 = 2.945, P = 0.229]; Liver [F (2, 21) = 6.214, P < 0.01]; Kidney [F (2, 21) = 4.945, P < 0.05]; Muscle [F (2, 21) = 1.554, P = 0.235]; Gut [H2 = 7.338, P < 0.05]; Vessels [F (2, 21) = 0.4566, P = 0.64]. *P < 0.05; **P < 0.01; ***P < 0.001. B Correlations between sEH levels and MWT scores in the mPFC (R2 = 0.4302, P < 0.01); C correlations between sEH levels and MWT scores in the hippocampus (R2 = 0.547, P < 0.01); D correlations between sEH levels and MWT scores in the spinal cord (R2 = 0.3576, P < 0.05); E correlations between sEH levels and MWT scores in the liver (R2 = 0.2829, P < 0.05); F correlations between sEH levels and MWT scores in the kidney (R2 = 0.8007, P < 0.001); G correlations between sEH levels and MWT scores in the gut (R2 = 0.476, P < 0.01); H correlations between MWT and SPT scores (R2 = 0.7731, P < 0.001). ACC anterior cingulate cortex, mPFC medial prefrontal cortex, MWT mechanical withdrawal threshold, NAc nucleus accumbens, NS not significant, SNI spared nerve injury, SPT sucrose preference test