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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway

Fig. 6

EGFR blocking antagonized the effects of ADAM12 in ccRCC. A CCK-8 assay revealed the viability of ACHN and 786-O cells treated with OE-ADAM12 lentivirus and the EGFR inhibitor gefitinib. B Colony formation assays showed the colony number of ACHN and 786-O cells treated with OE-ADAM12 lentivirus and gefitinib. C The wound healing assay showed the migration capacity of ACHN and 786-O cells treated with OE-ADAM12 lentivirus and gefitinib. D Transwell assay indicated the invasion capacity of ACHN and 786-O cells treated with OE-ADAM12 lentivirus and gefitinib. E, F Western blot assay revealed the expression of the indicated proteins in ACHN and 786-O cells treated with OE-ADAM12 lentivirus and gefitinib

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