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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway

Fig. 5

Silencing ADAM12 abolished the positive action of the EGFR activator on the proliferation, metastasis and EMT process of ccRCC cells. A CCK8 assay revealed the viability of CAKI-2 and 786-O cells treated with shADAM12 lentivirus and EGFR activator NSC228155. B Colony formation assays showed the colony number of CAKI-2 and 786-O cells treated with shADAM12 lentivirus and NSC228155. C The wound healing assay showed the migration capacity of CAKI-2 and 786-O cells treated with shADAM12 lentivirus and NSC228155. D Transwell assay indicated the invasion capacity of CAKI-2 and 786-O cells treated with shADAM12 lentivirus and NSC228155. E–F Western blot assay revealed the expression of the indicated proteins in CAKI-2 and 786-O cells treated with shADAM12 lentivirus and NSC228155

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