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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway

Fig. 1

ADAM12 was upregulated in ccRCC tissues and cell lines. A The expression of ADAM12 in ccRCC tissues was significantly higher than that in adjacent normal kidney tissues according to TCGA. B, C ADAM12 expression was positively associated with T stage and tumor stage in ccRCC patients. D The expression of ADAM12 was negatively correlated with overall survival in ccRCC patients. E GSE53757 data set showed a significantly higher expression of ADAM12 in ccRCC tissues. F, G GSE73731 data set revealed that the expression of ADAM12 in ccRCC was associated with tumor stage and grade. H, I The relative expression of ADAM12 in 30 pairs of ccRCC tissues and adjacent normal kidney tissues. Statistical analysis revealed that ADAM12 was dramatically upregulated in 30 ccRCC tissues compared to normal tissues. J IHC assays showed ADAM12 protein expression in different tumor stages of ccRCC tissues and adjacent normal kidney tissues. Scale bar = 50 μm. K, L The expression of ADAM12 in ccRCC cell lines and HK-2 cells at both the transcriptional and translational levels. *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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