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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: CD206+ tumor-associated macrophages interact with CD4+ tumor-infiltrating lymphocytes and predict adverse patient outcome in human laryngeal squamous cell carcinoma

Fig. 2

The infiltration pattern of CD68+CD206+ M2-like macrophages in the TME. A–C The infiltrating level of CD68 + CD206 + M2-like macrophages in tumor stroma A, tumor nest B, and corresponding adjacent normal tissue C. D Patients with LSCC exhibited different infiltrating levels of CD68+iNOS+ M1 and CD68+CD206+ M2 TAMs; Paired sample t test was used and statistical significance indicated as follows: ****p < 0.0001. E Immunofluorescent staining of patient tumor samples in cancer tissue and ANT region. Patients with positive E1 and negative E3 TS CD68+iNOS+ M1 TAM infiltration, and the CD68+iNOS+ M1 infiltration E2, E4; F Patients with positive F1 and negative F3 TN CD68+CD206+ M2 TAM infiltration, and the CD68+CD206+ M2 infiltration of their corresponding ANT F2, F4. G Patients with high G1 and low G3 levels of TS CD68+CD206+ M2 TAM infiltration, and the CD68+CD206+ M2 infiltration of their corresponding ANT G2, G4. LSCC, Laryngeal squamous cell carcinoma; TN, Tumor nest; TS, Tumor stroma; ANT, Adjacent normal tissue

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