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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Pan-cancer onco-signatures reveal a novel mitochondrial subtype of luminal breast cancer with specific regulators

Fig. 3

EMT markers together with Wnt/β-catenin signaling pathway members segregate Luminal breast tumors according to the cluster-assignment. A, B Results of the over-representation analysis performed by using the up-regulated (A) and the down-regulated (B) microRNAs derived by the differential expressed miRNA analysis. C Heatmap showing expression levels of the more representative epithelial–mesenchymal markers (Epi = epithelial, Mes = mesenchymal) and WNT (C-WNT = canonical WNT, NC-WNT = non canonical WNT) signaling pathway members in Cluster 2 and Cluster 4. The color key from blue to red indicates low to high gene expression, respectively. D Kaplan–Meier overall survival curves of TCGA primary Luminal A breast cancer cohort determined by comparing Cluster 2 vs Cluster 4. E Gene ontology enrichment analysis of the differentially expressed genes between Cluster 4 and Cluster 2 computed using only the Luminal A cohort. F Heatmap showing expression levels of the more representative epithelial–mesenchymal markers (Epi = epithelial, Mes = mesenchymal) and WNT (C-WNT = canonical WNT, NC-WNT = non canonical WNT) and signaling pathway members in Cluster 2 and Cluster 4 Luminal A samples

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