Fig. 2

Fut2 deficiency enhances promotion of AOM/DSS-induced CRC. A Schematic overview of this colon carcinogenesis model. B Body weight change during the disease process. C Survival rate of mice from each group. D Macroscopical changes in colon. Colons were removed at day 70 from treated WT and Fut2^△IEC mice, and representative results from 5 independent animals are shown here. E Tumor numbers of each group. F The typical images of mice colon tissues from treated WT and Fut2^△IEC mice. G The number of tumors corresponding to different tumor sizes of each group. Data are expressed as mean ± SEM. The data come from three independent experiments. In all panels: ***p < 0.001, ****p < 0.0001. (CRC colorectal cancer, AOM/DSS azoxymethane/dextran sodium sulfate, WT wild type, SEM Standard Error of Mean)