Table 2 Candidate genes for gene over-representation analyses
Gene | Gene name | Chr | Type | Primary molecular function |
|---|---|---|---|---|
APC | APC, WNT signaling pathway regulator | 5 | Protein coding | Tumor suppressor |
BRCA1 | BRCA1, DNA repair associated | 17 | Protein coding | Facilitating cellular responses to DNA damage |
CLOCK | Clock circadian regulator | 4 | Protein coding | Transcriptional activator as a core component of the circadian clock |
GRIN3B | Glutamate ionotropic receptor nmda type subunit 3b | 19 | Protein coding | N-methyl-D-aspartate receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium |
GSK3B | Glycogen synthase kinase 3 beta | 3 | Protein coding | A negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules |
KRT8P38M | Keratin 8 pseudogene 38 | 10 | Pseudogene | NA |
LIPFM | Lipase F, gastric type | 10 | Protein coding | Catalyzing the hydrolysis of triacylglycerols to free fatty acids, diacylglycerol, monoacylglycerol, and glycerol |
LIPJM | Lipase family member J | 10 | Protein coding | Enabling hydrolase activity, acting on ester bonds |
LIPKM | Lipase family member K | 10 | Protein coding | Playing a highly specific role in the last step of keratinocyte differentiation; may have an essential function in lipid metabolism of the most differentiated epidermal layer |
LIPNM | Lipase family member N | 10 | Protein coding | Same as the LIPK |
NR3C1 | Nuclear receptor subfamily 3 group C member 1 | 5 | Protein coding | Receptor for glucocorticoids |
PRDM16 | PR/SET domain 16 | 1 | Protein coding | Binds DNA and functions as a transcriptional regulator |
RNLSM | Renalase, FAD dependent amine oxidase | 10 | Protein coding | Catalyzing the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to beta-NAD(P)( +) |
SALL3 | Spalt like transcription factor 3 | 18 | Protein coding | Probable transcription factor |
SLC12A8S | Solute carrier family 12 member 8 | 3 | Protein coding | Ation/chloride cotransporter that may play a role in the control of keratinocyte proliferation |
SYCP2 | Synaptonemal complex protein 2 | 20 | Protein coding | Major component of the axial/lateral elements of synaptonemal complexes during meiotic prophase |
TMEM259 | Transmembrane protein 259 | 19 | Protein coding | May have a role in the endoplasmic-reticulum-associated protein degradation (ERDA) pathway required for clearance of misfolded proteins in the ER; promoting survival of motor neurons |
TPH1 | Tryptophan hydroxylase 1 | 11 | Protein coding | Oxidizing L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis |
TPH2 | Tryptophan hydroxylase 2 | 12 | Protein coding | Enabling tryptophan 5-monooxygenase activity |