Fig. 3

Tumor-derived factors and skeletal muscle connectome. Left: alluvial diagram connecting the ligands from the upregulated genes in LM into its matched skeletal muscle receptors. Right: Heatmap of the expression levels of predicted receptors in human primary cell lineages, previously described by Ramilowski et al. [16] (red: Transcripts Per Million—TPM), four skeletal muscle tissues from BioGPS (gray: median gcRMA), and 491 skeletal muscle samples from the Genotype-Tissue Expression (GTEx) project (green: Trimmed Mean of M-values—TMM)