Fig. 5
The effect of lncRNA Kcnq1ot1 knockdown on miR-34a-5p and Sirt1 expression in cardiomyocytes. A The expression of lncRNA Kcnq1ot1 was downregulated in si-Kcnq1ot1-transfected cardiomyocytes. B Knockdown of lncRNA Kcnq1ot1 decreased the viability of mouse cardiomyocytes. C Knockdown of lncRNA Kcnq1ot1 increased the inhibition rate of mouse cardiomyocytes. D Knockdown of lncRNA Kcnq1ot1 upregulated miR-34a-5p expression in cardiomyocytes. E Knockdown of lncRNA Kcnq1ot1 downregulated Sirt1 mRNA expression in cardiomyocytes. F Knockdown of lncRNA Kcnq1ot1 downregulated Sirt1 protein expression in cardiomyocytes. *P < 0.05, **P < 0.01 vs. si-NC group; n = 3–6