Fig. 8

Hyperglycemic effects in zebrafish models. A The hyperglycemia conditions (2% and 5% glucose) altered angiogenic marker expression levels. Increased levels of miR-223-3p were associated with increased expression of VEGF receptors (FTL-1 and KDR) at 2% glucose condition compared to the control group. The Control group at 5% glucose condition showed increased VEGF expression levels. B The hyperglycemia conditions were associated with the upregulation of pancreatic markers within the mimic miR-223-3p group. C The control group showed increased expression levels of apoptotic markers at 5% glucose. Expression was analyzed as described in Fig. 7