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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Low expression of the dynamic network markers FOS/JUN in pre-deteriorated epithelial cells is associated with the progression of colorectal adenoma to carcinoma

Fig. 5

Intercellular communication contributes to epithelial cell deterioration. A Chord plot shows the interactions among cell subpopulations on the epithelial cell deterioration trajectory through the GDF signaling pathway. B Chord plot shows the interactions among cell populations in the TME through the CEACAM signaling pathway. C Chord plot shows the interactions among cell populations in the TME through the GRN signaling pathway. D The expression of GDF15 in before-deterioration stage and deteriorated stage. Differences in expression are checked using the Wilcox test. E Cytoscape visualization of the protein–protein interaction network. Red rectangles represent DNB-genes, and blue rectangles represent DNB-neighboring genes. Genes that directly engaged in the network are represented by the solid green line, and genes that indirectly engaged in the network are represented by the orange dotted line

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