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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Low expression of the dynamic network markers FOS/JUN in pre-deteriorated epithelial cells is associated with the progression of colorectal adenoma to carcinoma

Fig. 3

Identification of epithelial cell subtype. A The graph on the left demonstrates that the curve of SCLE score \({H}_{t}\) defined in Materials and Methods suddenly increases as the system approaches the critical point (p = 0), which is considered as a critical state transition at a bifurcation point. The graph on the right demonstrates that pre-deteriorated epithelial cells were in the critical state and potential trajectory of epithelial cell deterioration is same as Fig. 2D. B The graph shows the PPI network of DNB core genes. C Function analysis (GSVA) demonstrates that various gene sets may have varying effects on the progression of epithelial cell deterioration. Pathways that were significantly enriched in the pre-deterioration stage are marked in red. Limma was used to compare enrichment score between before-deterioration stage and pre-deterioration stage, as well as between pre-deterioration stage and deteriorated stage. D The heatmap demonstrates the TF regulatory activity (AUC z-score) estimated using SCENIC analysis. The five TFs with increased transcriptional activity were chosen for visualization in before-deterioration stage and deteriorated stage, respectively. Limma was used to compare AUC discrepancies between before-deterioration stage and pre-deterioration stage, as well as between pre-deterioration stage and deteriorated stage

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