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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Tanshinone IIA ameliorates Aβ transendothelial transportation through SIRT1-mediated endoplasmic reticulum stress

Fig. 7

Scheme depicting the mechanism by which Tanshinone IIA (Tan IIA) regulates the function of brain microvascular endothelial cells (BMECs) to improve cognitive deficits in APP/PS1 mice. Tan IIA attenuates SIRT1-mediated endoplasmic reticulum stress and improves Aβ transendothelial transportation by regulating LRP1 and RAGE in BMECs, while it boosts the energy metabolism, reduces oxidative stress, alleviates neurodegeneration, and hinders neuronal apoptosis in neurons

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