Fig. 6

Tan IIA promotes Aβ transendothelial transportation in BMECs of APP/PS1 mice. a indirect immunofluorescence of the Aβ aggregation in vascular endothelium of APP/PS1 mice. b Thioflavin T staining of the Aβ aggregation in hippocampus and cortex of mice. c-e Western blot analysis of LRP1 and RAGE in APP/PS1 mice: d LRP1; e RAGE. f, g Indirect immunofluorescence of LRP1 (f) and RAGE (g) in the vascular endothelium of APP/PS1 mice. Scale bar, 50 μm; inset, 20 μm. Tan-L: Tan IIA (10 mg/kg/d); Tan-H: Tan IIA (20 mg/kg/d). The mean ± SD was calculated based on three separate studies. *P < 0.05, **P < 0.01