Fig. 4

Tan IIA reduces oxidative stress, alleviates neurodegeneration, and prevents neuronal apoptosis in APP/PS1 mice. a Axial, sagittal, and axial views of mice were evaluated by ¹⁸ F-FDG PET/CT. b-e The levels of CAT, MDA, T-SOD, and GSH-PX were detected by kits. f–i Western blot analysis of PSD95 (g), BDNF (h), and NGF (i). j Nissl’s staining in hippocampus and cortex. k-m Western blot analysis of Caspase-3 (l) and Bax/ Bcl-2 (m). Scale bar is 50 μm. Tan-L: Tan IIA (10 mg/kg/d); Tan-H: Tan IIA (20 mg/kg/d). The mean ± SD was calculated based on three separate studies, *P < 0.05, **P < 0.01