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Table 2 Conditional logical regression measured odds ratios of chronic fatigue syndrome with different treatments

From: Presence of depression and anxiety with distinct patterns of pharmacological treatments before the diagnosis of chronic fatigue syndrome: a population-based study in Taiwan

Variable

N

Control

CFS

Odds ratio

Multiple comparisons

n

%

n

%

Crude (95% CI)

p-value

Adjusted (95% CI)

p-value

p-value

SSRI

     

1.90 (1.68,2.14)***

 < 0.001

1.21 (1.04,1.39)*

0.011

0.001

 No

11,365

5858

52%

5507

48%

     

 Yes

1247

448

36%

799

64%

     

SNRI

     

2.11 (1.65,2.70)***

 < 0.001

1.27 (0.97,1.67)

0.080

0.006

 No

12,320

6211

50%

6109

50%

     

 Yes

292

95

33%

197

67%

     

SARI

     

2.85 (2.46,3.31)***

 < 0.001

1.87 (1.59,2.19)***

 < 0.001

 < 0.001

 No

11,684

6052

52%

5632

48%

     

 Yes

928

254

27%

674

73%

     

TCAs

     

2.04 (1.55,2.68)***

 < 0.001

1.46 (1.09,1.95)**

0.010

0.001

 No

12,374

6227

50%

6147

50%

     

 Yes

238

79

33%

159

67%

     

NDRI

     

1.85 (1.20,2.85)**

0.005

0.85 (0.53,1.36)

0.495

0.035

 No

12,521

6274

50%

6247

50%

     

 Yes

91

32

35%

59

65%

     

NaSSA

     

2.04 (1.51,2.74)***

 < 0.001

1.12 (0.81,1.54)

0.508

0.036

 No

12,413

6240

50%

6173

50%

     

 Yes

199

66

33%

133

67%

     

BZD

     

2.14 (1.98,2.32)***

 < 0.001

1.60 (1.46,1.76)***

 < 0.001

 < 0.001

 No

3680

2328

63%

1352

37%

     

 Yes

8932

3978

45%

4954

55%

     

Muscle relaxant

     

2.16 (1.74,2.69)***

 < 0.001

1.74 (1.39,2.19)***

 < 0.001

 < 0.001

 No

12,229

6183

51%

6046

49%

     

 Yes

383

123

32%

260

68%

     

Analgesic drug

    

4.43 (3.96,4.97)***

 < 0.001

3.56 (3.16,4.00)***

 < 0.001

 < 0.001

 No

1995

1560

78%

435

22%

     

 Yes

10,617

4746

45%

5871

55%

     

Supportive individual psychotherapy

     

1.10 (0.94,1.29)

0.229

1.09 (0.92,1.29)

0.302

0.022

 No

11,956

5993

50%

5963

50%

     

 Yes

656

313

48%

343

52%

     

Re-educative group psychotherapy

     

0.60 (0.33,1.08)

0.086

0.56 (0.30,1.04)

0.065

0.005

 No

12,564

6276

50%

6288

50%

     

 Yes

48

30

63%

18

38%

     

Stretching exercise

     

1.08 (0.94,1.25)

0.280

1.07 (0.92,1.24)

0.367

0.026

 No

11,788

5909

50%

5879

50%

     

 Yes

824

397

48%

427

52%

     

Therapeutic exercise

   

1.09 (0.98,1.22)

0.126

1.08 (0.96,1.22)

0.182

0.013

 No

11,273

5663

50%

5610

50%

     

 Yes

1339

643

48%

696

52%

     

Brainwave examination, sleep or wakefulness

     

1.60 (1.44,1.77)***

 < 0.001

1.05 (0.91,1.21)

0.527

0.038

 No

11,704

5864

50%

5840

50%

     

 Yes

908

442

49%

466

51%

     
  1. CFS chronic fatigue syndrome, CI confidence interval, SSRI selective serotonin reuptake inhibitor, SNRI serotonin and norepinephrine reuptake inhibitor, SARI serotonin antagonist and reuptake inhibitor, TCA tricyclic antidepressants, NDRI norepinephrine and dopamine reuptake inhibitor, NaSSA noradrenergic and specific serotonergic antidepressants, BZD benzodiazepine
  2. *P < .05, **P < .01, ***P < .001