Variable | CFS cohort | Non-CFS cohort | P-value |
---|---|---|---|
(n = 6306) | (n = 6306) | ||
Gender |  |  |  > 0.99 |
 Female | 3339 (52.9) | 3339 (52.9) |  |
 Male | 2967 (47.1) | 2967 (47.1) |  |
Age at diagnosis of CFS |  |  |  > 0.99 |
  ≤ 34 | 1350 (21.4) | 1350 (21.4) |  |
 35–64 | 3485 (55.3) | 3485 (55.3) |  |
  ≥ 65 | 1471 (23.3) | 1471 (23.3) |  |
 Age at diagnosis of CFS(mean, SD)†| 50.6 (17.9) | 50.6 (18.0) | 0.80 |
Comorbidity | |||
 Depression | 807 (12.8) | 407 (6.45) |  < 0.0001 |
 Anxiety disorder | 2038 (32.3) | 1033 (16.4) |  < 0.0001 |
 Insomnia | 2303 (36.5) | 1106 (17.5) |  < 0.0001 |
 Irritable bowel syndrome | 886 (14.1) | 423 (6.71) |  < 0.0001 |
 Crohn's disease | 255 (4.04) | 121 (1.92) |  < 0.0001 |
 Ulcerative colitis | 279 (4.42) | 138 (2.19) |  < 0.0001 |
 Rheumatoid arthritis | 254 (4.03) | 155 (2.46) |  < 0.0001 |
 Sjogren's syndrome | 110 (1.74) | 71 (1.13) | 0.003 |
 Psoriasis | 94 (1.49) | 83 (1.32) | 0.40 |
 Ankylosing spondylitis | 53 (0.84) | 39 (0.62) | 0.14 |
 Hashimoto's thyroiditis | 13 (0.21) | 10 (0.16) | 0.53 |
 T1DM | 78 (1.24) | 68 (1.08) | 0.40 |
 T2DM | 1473 (23.3) | 1068 (16.9) |  < 0.0001 |
 Gout | 1196 (18.9) | 702 (11.1) |  < 0.0001 |
 Dyslipidemia | 2252 (35.7) | 1356 (21.5) |  < 0.0001 |
 Renal disease | 585 (9.28) | 427 (6.77) |  < 0.0001 |