Fig. 5

Increased level of sPD-L1 was potential to predict progressive disease on combination immunotherapy for patients with pMMR CRC. sPD-L1 level at C1 a or C4 b showed no significant difference according to treatment outcome. c Comparison of changes in in level of sPD-1 between C1 and C4. d An increase in sPD-L1 level is associated with inferior response to combination immunotherapy. C1, cycle 1; C4, cycle 4