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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Fig. 1

Mitochondrial homeostasis is maintained by MQC system. Mitochondrial quality control system is composed of the balance between fusion (A) and fission (B), and between biogenesis (C) and mitophagy (D). A. Fusion. Mitochondria mediate fusion of IMM and OMM through OPA1 and MFN1/2. B. Fission. Mitochondria complete fission through fission-related factors such as DRP1 and dynein. C. Mitochondrial biogenesis. AMPK and SIRT1 pathways activate the PGC-1α/NRF1/2/TAFM axis and affect mitochondrial biogenesis. D. Mitophagy. Mitochondrial mitophagy is initiated to eliminate damaged mitochondria generated from disrupted fission and fusion

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