Fig. 4

A FASN expression by Western blot analysis in PL-45, SW1990, LNCaP, and C4-2 cells with relative abundance. Statistical significance with two sample t-test between PDAC and PCa cell lines reported as **p < 0.01. B Viability assay in PDAC systems (PL-45 and SW1990). TVB-2640 was used at a final concentration of 1 μM, 5 μM, 10 μM, 25 μM, and 50 μM for 24 h, 48 h, and 72 h. C Proliferation assay in PCa systems (LNCaP and C4-2). TVB-2640 was used at a final concentration of 1 μM, 5 μM, 10 μM, 25 μM, and 50 μM for 24 h, 48 h, and 72 h. D Oxygen consumption rate (OCR) for basal respiration, maximal respiration, and ATP production in PL-45, SW1990, LNCaP, and C4-2 cells after TVB-2640 treatment at 50 μM for 6 h. Statistical significance with two sample t-test reported as *,**,*** p < 0.05, < 0.01, < 0.001