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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway

Fig. 5

AFAP1L1 is associated with integrin signaling and promotes ITGA5 expression in GC. A, B GO enrichment analysis (A) and KEGG pathway analysis (B) were performed by differentially expressed genes (DEGs) between AFAP1L1 high- and low-expression group in TCGA STAD database. The top 30 pathways were shown in bubble diagrams. C Representative results of integrin-related pathways from Gene Set Enrichment Analysis (GSEA) of AFAP1L1 in TCGA STAD database. D Pearson correlation analysis of AFAP1L1 and ITGA5 in GC using data from TCGA STAD database. E Analysis using TCGA STAD database showed ITGA5 expression in GC tissues and normal gastric tissues and its effect on prognosis of GC patients. F Western blot analysis to detect the effect of AFAP1L1 overexpression or knockdown on the expression of ITGA5, ITGB3 and integrin downstream effectors FAK, ERK. p-FAK and p-ERK represented their activation forms. G The representative IHC images from serial sections of GC samples showed AFAP1L1, ITGA5, p-FAK and p-ERK expression in GC tissues with high or low AFAP1L1 expression

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