Cell type | Gene markers | HLA-DPA1 | CD4 | ||||||
---|---|---|---|---|---|---|---|---|---|
None | Purity | None | Purity | ||||||
Cor | p-value | cor | p-value | Cor | p-value | Cor | p-value | ||
CD8 + T | CD8A | 8.06E-01 | 0.00E + 00 | −2.77E-01 | 4.03E-10 | 7.48E-01 | 1.75E-89 | −2.77E-01 | 4.03E-10 |
CD8B | 7.65E-01 | 1.45E−101 | −2.42E-01 | 5.06E-08 | 7.15E-01 | 2.38E-78 | −2.42E-01 | 5.06E-08 | |
T cell (general) | CD3D | 8.01E-01 | 0.00E + 00 | −2.98E-01 | 1.35E-11 | 7.46E-01 | 1.47E-88 | −2.98E-01 | 1.35E-11 |
CD3E | 8.47E-01 | 9.59E−145 | −2.99E-01 | 1.17E-11 | 8.43E-01 | 2.18E-134 | −2.99E-01 | 1.17E-11 | |
CD2 | 8.50E-01 | 0.00E + 00 | −2.85E-01 | 1.15E-10 | 8.36E-01 | 3.54E-130 | −2.85E-01 | 1.15E-10 | |
B cell | CD19 | 4.77E-01 | 5.74E−31 | −2.61E-01 | 4.33E-09 | 5.05E-01 | 2.74E-33 | −2.61E-01 | 4.33E-09 |
CD79A | 4.71E-01 | 3.47E−30 | −2.28E-01 | 3.05E-07 | 5.12E-01 | 2.50E-34 | −2.28E-01 | 3.05E-07 | |
Monocyte | CD86 | 7.73E-01 | 0.00E + 00 | −2.95E-01 | 2.26E-11 | 8.45E-01 | 2.22E-135 | −2.95E-01 | 2.26E-11 |
CD115 (CSF1R) | 8.33E-01 | 6.76E−136 | −3.04E-01 | 4.98E-12 | 9.39E-01 | 5.83E-230 | −3.04E-01 | 4.98E-12 | |
TAM | CCL2 | 5.50E-01 | 0.00E + 00 | −2.58E-01 | 5.98E-09 | 6.13E-01 | 2.64E-52 | −2.58E-01 | 5.98E-09 |
CD68 | 4.52E-01 | 0.00E + 00 | −1.72E-01 | 1.24E-04 | 5.68E-01 | 1.75E-43 | −1.72E-01 | 1.24E-04 | |
IL10 | 5.57E-01 | 7.92E−44 | −3.13E-01 | 1.21E-12 | 6.28E-01 | 1.74E-55 | −3.13E-01 | 1.21E-12 | |
M1 macrophage | INOS (NOS2) | 2.55E-01 | 3.57E−09 | 7.08E-02 | 1.16E-01 | 2.96E-01 | 2.09E-11 | 7.08E-02 | 1.16E-01 |
IRF5 | 3.14E-01 | 3.02E−13 | −1.43E-03 | 9.75E-01 | 3.82E-01 | 1.44E-18 | −1.43E-03 | 9.75E-01 | |
M2 macrophage | COX2 (PTGS2) | -1.53E-01 | 4.45E−04 | 9.98E-02 | 2.67E-02 | -1.55E-01 | 5.32E-04 | 9.98E-02 | 2.67E-02 |
CD163 | 6.89E-01 | 0.00E + 00 | −2.86E-01 | 1.02E-10 | 8.07E-01 | 2.37E-114 | −2.86E-01 | 1.02E-10 | |
VSIG4 | 6.22E-01 | 0.00E + 00 | −2.57E-01 | 7.42E-09 | 7.53E-01 | 3.02E-91 | −2.57E-01 | 7.42E-09 | |
MS4A4A | 7.38E-01 | 5.15E−91 | −2.87E-01 | 8.35E-11 | 8.38E-01 | 1.73E-131 | −2.87E-01 | 8.35E-11 | |
Neutr-ophils | CD66b (CEACAM8) | 5.92E-02 | 1.77E−01 | 3.42E-02 | 4.48E-01 | 4.51E-02 | 3.18E-01 | 3.42E-02 | 4.48E-01 |
CD11b (ITGAM) | 6.00E-01 | 2.39E−52 | −1.37E-01 | 2.27E-03 | 7.20E-01 | 7.13E-80 | −1.37E-01 | 2.27E-03 | |
CCR7 | 6.52E-01 | 1.71E−64 | −3.22E-01 | 2.23E-13 | 7.38E-01 | 9.46E-86 | −3.22E-01 | 2.23E-13 | |
NK cell | KIR2DL1 | 3.81E-01 | 1.69E−19 | −9.34E-02 | 3.81E-02 | 3.44E-01 | 4.23E-15 | −9.34E-02 | 3.81E-02 |
KIR2DL3 | 5.10E-01 | 6.99E−36 | −1.36E-01 | 2.56E-03 | 4.69E-01 | 2.57E-28 | −1.36E-01 | 2.56E-03 | |
KIR2DL4 | 6.02E-01 | 7.92E−53 | −1.83E-01 | 4.30E-05 | 4.95E-01 | 7.06E-32 | −1.83E-01 | 4.30E-05 | |
KIR3DL1 | 4.47E-01 | 4.78E−27 | −1.44E-01 | 1.35E-03 | 4.27E-01 | 2.70E-23 | −1.44E-01 | 1.35E-03 | |
KIR3DL2 | 5.74E-01 | 4.40E−47 | −1.47E-01 | 1.05E-03 | 5.56E-01 | 2.63E-41 | −1.47E-01 | 1.05E-03 | |
KIR3DL3 | 2.33E-01 | 7.00E−08 | −8.59E-02 | 5.68E-02 | 2.05E-01 | 4.56E-06 | −8.59E-02 | 5.68E-02 | |
KIR2DS4 | 3.47E-01 | 2.92E−16 | −1.48E-01 | 9.93E-04 | 3.32E-01 | 4.09E-14 | −1.48E-01 | 9.93E-04 | |
Dend-ritic cell | HLA-DPB1 | 9.57E-01 | 0.00E + 00 | −3.02E-01 | 7.78E-12 | 8.70E-01 | 1.09E-152 | −3.02E-01 | 7.78E-12 |
HLA-DQB1 | 8.14E-01 | 6.55E−125 | −2.28E-01 | 3.28E-07 | 7.03E-01 | 1.07E-74 | −2.28E-01 | 3.28E-07 | |
HLA-DRA | 9.74E-01 | 0.00E + 00 | −2.99E-01 | 1.16E-11 | 8.51E-01 | 1.33E-139 | −2.99E-01 | 1.16E-11 | |
BDCA-1 | 5.37E-01 | 2.59E−40 | −2.57E-01 | 7.19E-09 | 6.25E-01 | 1.07E-54 | −2.57E-01 | 7.19E-09 | |
BDCA-4 | 4.59E-01 | 1.61E−28 | −2.07E-01 | 3.38E-06 | 5.65E-01 | 6.16E-43 | −2.07E-01 | 3.38E-06 | |
CD11c | 6.45E-01 | 1.01E−62 | −2.83E-01 | 1.53E-10 | 7.89E-01 | 7.01E-106 | −2.83E-01 | 1.53E-10 | |
T-bet (TBX21) | 7.88E-01 | 9.07E−112 | −2.44E-01 | 4.20E-08 | 7.68E-01 | 2.85E-97 | −2.44E-01 | 4.20E-08 | |
Th1 | STAT4 | 6.52E-01 | 0.00E + 00 | −2.61E-01 | 3.96E-09 | 6.94E-01 | 6.30E-72 | −2.61E-01 | 3.96E-09 |
STAT1 | 6.26E-01 | 0.00E + 00 | −2.40E-01 | 7.06E-08 | 5.29E-01 | 5.97E-37 | −2.40E-01 | 7.06E-08 | |
IFN-y(IFNG) | 7.09E-01 | 5.81E−81 | −2.34E-01 | 1.49E-07 | 5.79E-01 | 2.19E-45 | −2.34E-01 | 1.49E-07 | |
TNF-a(TNF) | 2.28E-01 | 1.47E−07 | −1.27E-01 | 4.90E-03 | 2.26E-01 | 4.19E-07 | −1.27E-01 | 4.90E-03 | |
Th2 | GATA3 | 4.56E-01 | 3.72E−28 | −2.27E-01 | 3.63E-07 | 4.93E-01 | 1.61E-31 | −2.27E-01 | 3.63E-07 |
STAT5A | 6.20E-01 | 8.53E−57 | −1.32E-01 | 3.28E-03 | 6.43E-01 | 9.08E-59 | −1.32E-01 | 3.28E-03 | |
STAT6 | 2.90E-01 | 1.73E−11 | 6.90E-02 | 1.26E-01 | 3.25E-01 | 1.31E-13 | 6.90E-02 | 1.26E-01 | |
IL13 | 4.10E-01 | 1.52E−22 | −1.54E-01 | 5.78E-04 | 4.22E-01 | 1.06E-22 | −1.54E-01 | 5.78E-04 | |
Tfh | BCL6 | 8.87E-02 | 4.28E−02 | 1.75E-01 | 8.98E-05 | 1.69E-01 | 1.57E-04 | 1.75E-01 | 8.98E-05 |
IL21 | 5.20E-01 | 2.03E−37 | −1.75E-01 | 9.02E-05 | 5.12E-01 | 2.50E-34 | −1.75E-01 | 9.02E-05 | |
Th17 | STAT3 | 3.84E-01 | 0.00E + 00 | −1.69E-02 | 7.08E-01 | 4.09E-01 | 2.82E-21 | −1.69E-02 | 7.08E-01 |
IL17A | 2.85E-01 | 3.45E−11 | −1.02E-01 | 2.40E-02 | 2.74E-01 | 6.59E-10 | −1.02E-01 | 2.40E-02 | |
Treg | FOXP3 | 7.93E-01 | 0.00E + 00 | −2.53E-01 | 1.18E-08 | 8.70E-01 | 9.39E-153 | −2.53E-01 | 1.18E-08 |
CCR8 | 6.88E-01 | 2.64E−74 | −2.34E-01 | 1.39E-07 | 7.89E-01 | 4.56E-106 | −2.34E-01 | 1.39E-07 | |
STAT5B | 3.76E-01 | 6.17E−19 | −5.12E-02 | 2.56E-01 | 4.91E-01 | 2.65E-31 | −5.12E-02 | 2.56E-01 | |
TGFb(TGFb1) | 4.60E-02 | 2.95E−01 | −1.42E-01 | 1.55E-03 | 1.36E-01 | 2.39E-03 | −1.42E-01 | 1.55E-03 | |
T-cell -exhau-stion | PD-1(PDCD1) | 8.20E-01 | 7.03E−128 | −2.68E-01 | 1.57E-09 | 7.74E-01 | 1.45E-99 | −2.68E-01 | 1.57E-09 |
CTLA4 | 7.66E-01 | 0.00E + 00 | −3.10E-01 | 2.04E-12 | 7.69E-01 | 1.14E-97 | −3.10E-01 | 2.04E-12 | |
LAG3 | 7.67E-01 | 2.04E−102 | −2.37E-01 | 9.98E-08 | 6.97E-01 | 7.88E-73 | −2.37E-01 | 9.98E-08 | |
TIM-3(HAVCR2) | 8.68E-01 | 0.00E + 00 | −2.77E-01 | 3.81E-10 | 9.26E-01 | 2.09E-209 | −2.77E-01 | 3.81E-10 | |
GZMB | 7.22E-01 | 0.00E + 00 | −2.64E-01 | 2.68E-09 | 6.14E-01 | 2.30E-52 | −2.64E-01 | 2.68E-09 |